L'orario della scadenza è relativo alla prima partita in programma.
Fra parentesi il numero di utenti che hanno scelto la squadra.
Day 1 - Scadenza: 21/2, h.20
| St. Louis City (2) | Charlotte | 1-1 |
| Cincinnati (4) | Atlanta Utd | 2-0 |
| DC United (2) | Philadelphia Union | 1-0 |
| Orlando City | New York Red Bulls | 1-2 |
| Vancouver Whitecaps (12) | Real Salt Lake | 1-0 |
| Austin FC | Minnesota | 2-2 |
| Houston Dynamo (2) | Chicago Fire | 2-1 |
| Nashville SC (2) | New England Revolution | 4-1 |
| FC Dallas (2) | Toronto FC | 3-2 |
| Los Angeles FC (1) | Inter Miami | 3-0 |
| Portland Timbers | Columbus Crew | 3-2 |
| San Jose Earthquakes | Sporting Kansas City | 3-0 |
| San Diego FC (24) | CF Montreal | 5-0 |
| Los Angeles Galaxy (4) | New York City | 1-1 |
| Seattle Sounders (12) | Colorado Rapids | 2-0 |
|
Day 2 - Scadenza: 28/2, h.20
| New York Red Bulls | New England Revolution | 1-0 |
| Chicago Fire | CF Montreal | 3-0 |
| Colorado Rapids | Portland Timbers (8) | 2-0 |
| Minnesota | Cincinnati (1) | 1-0 |
| Real Salt Lake | Seattle Sounders (7) | 2-1 |
| San Jose Earthquakes | Atlanta Utd (1) | 2-0 |
| FC Dallas | Nashville SC (3) | 0-0 |
| Houston Dynamo | Los Angeles FC (9) | 0-2 |
| Sporting Kansas City | Columbus Crew (35) | 2-2 |
| Vancouver Whitecaps | Toronto FC | 3-0 |
| Los Angeles Galaxy | Charlotte | 3-0 |
| Austin FC | DC United (1) | 1-0 |
| Philadelphia Union | New York City | 1-2 |
| Orlando City | Inter Miami (3) | 2-4 |
| San Diego FC | St. Louis City | 2-0 |
|
Day 3 - Scadenza: 7/3, h.20
| New England Revolution | Houston Dynamo | 7/3 20:30 |
| New York City (6) | Orlando City | 5-0 |
| DC United | Inter Miami | 1-2 |
| Atlanta Utd | Real Salt Lake | 2-3 |
| Charlotte | Austin FC | 3-1 |
| Columbus Crew | Chicago Fire | 0-0 |
| Philadelphia Union (1) | San Jose Earthquakes | 0-1 |
| Sporting Kansas City | San Diego FC | 0-1 |
| Nashville SC | Minnesota | 3-1 |
| St. Louis City | Seattle Sounders | 0-1 |
| Colorado Rapids | Los Angeles Galaxy | 4-1 |
| Los Angeles FC (19) | FC Dallas | 1-0 |
| Portland Timbers | Vancouver Whitecaps | 1-4 |
| New York Red Bulls (41) | CF Montreal | 0-3 |
| Cincinnati (1) | Toronto FC | 0-1 |
|
Day 4 - Scadenza: 14/3, h.18
| Toronto FC | New York Red Bulls (3) | 1-1 |
| Atlanta Utd | Philadelphia Union (2) | 3-1 |
| Columbus Crew | Nashville SC (6) | 0-1 |
| Charlotte | Inter Miami (24) | 0-0 |
| New York City | Colorado Rapids | 3-1 |
| Orlando City | CF Montreal (8) | 2-1 |
| Chicago Fire | DC United | 1-2 |
| FC Dallas | San Diego FC (17) | 3-3 |
| Houston Dynamo | Portland Timbers | 3-2 |
| Los Angeles Galaxy | Sporting Kansas City | 1-2 |
| Real Salt Lake | Austin FC (1) | 2-1 |
| Los Angeles FC | St. Louis City | 2-0 |
| New England Revolution | Cincinnati (4) | 6-1 |
| Vancouver Whitecaps | Minnesota | 6-0 |
| San Jose Earthquakes | Seattle Sounders | 0-1 |
|
Day 5 - Scadenza: 21/3, h.18
| Toronto FC | Columbus Crew (1) | 2-1 |
| Philadelphia Union | Chicago Fire (4) | 1-2 |
| Nashville SC | Orlando City | 5-0 |
| Atlanta Utd | DC United | 0-0 |
| Charlotte | New York Red Bulls | 6-1 |
| FC Dallas | Houston Dynamo | 4-3 |
| Sporting Kansas City | Colorado Rapids | 1-4 |
| St. Louis City | New England Revolution | 3-1 |
| Austin FC | Los Angeles FC (7) | 0-0 |
| Vancouver Whitecaps | San Jose Earthquakes | 0-1 |
| New York City | Inter Miami | 2-3 |
| Cincinnati | CF Montreal | 4-3 |
| Minnesota | Seattle Sounders | 0-0 |
| Portland Timbers | Los Angeles Galaxy | 1-1 |
| San Diego FC | Real Salt Lake | 2-2 |
|
Day 6 - Scadenza: 4/4, h.19
| Toronto FC | Colorado Rapids (2) | 3-2 |
| Real Salt Lake | Sporting Kansas City | 3-1 |
| New England Revolution | CF Montreal | 3-0 |
| Atlanta Utd | Columbus Crew (2) | 1-3 |
| Charlotte | Philadelphia Union | 2-1 |
| DC United | FC Dallas (3) | 0-4 |
| Inter Miami | Austin FC | 2-2 |
| New York City | St. Louis City | 1-1 |
| New York Red Bulls | Cincinnati | 4-2 |
| Chicago Fire | Nashville SC (22) | 1-0 |
| Houston Dynamo | Seattle Sounders (36) | 0-1 |
| Los Angeles FC | Orlando City | 6-0 |
| Los Angeles Galaxy | Minnesota (1) | 1-2 |
| San Jose Earthquakes | San Diego FC (1) | 3-0 |
| Vancouver Whitecaps | Portland Timbers | 3-2 |
|
Day 7 - Scadenza: 11/4, h.19
| Toronto FC | Cincinnati | 1-1 |
| Austin FC | Los Angeles Galaxy | 1-2 |
| CF Montreal (15) | Philadelphia Union | 1-2 |
| Portland Timbers | Los Angeles FC | 2-1 |
| Charlotte | Nashville SC | 1-2 |
| Inter Miami (11) | New York Red Bulls | 2-2 |
| New England Revolution (2) | DC United | 1-0 |
| Vancouver Whitecaps (3) | New York City | 2-0 |
| Chicago Fire (17) | Atlanta Utd | 1-0 |
| FC Dallas (4) | St. Louis City | 1-1 |
| Sporting Kansas City (1) | San Jose Earthquakes | 1-3 |
| Colorado Rapids (1) | Houston Dynamo | 6-2 |
| San Diego FC | Minnesota | 1-2 |
| Columbus Crew (10) | Orlando City | 1-1 |
| Seattle Sounders (1) | Real Salt Lake | 13/4 03:00 |
|
Day 8 - Scadenza: 18/4, h.04
| Vancouver Whitecaps | Sporting Kansas City | 3-0 |
| Toronto FC | Austin FC | 3-3 |
| CF Montreal | New York Red Bulls (31) | 4-1 |
| Colorado Rapids | Inter Miami (5) | 2-3 |
| Atlanta Utd | Nashville SC (19) | 0-2 |
| Cincinnati | Chicago Fire (8) | 3-3 |
| New England Revolution | Columbus Crew | 2-1 |
| New York City | Charlotte | 1-2 |
| Orlando City | Houston Dynamo (2) | 0-1 |
| Philadelphia Union | DC United (1) | 0-0 |
| FC Dallas | Los Angeles Galaxy | 2-2 |
| Minnesota | Portland Timbers | 2-0 |
| Real Salt Lake | San Diego FC | 4-2 |
| Seattle Sounders | St. Louis City | 4-1 |
| Los Angeles FC | San Jose Earthquakes (1) | 1-4 |
|
Day 9 - Scadenza: 23/4, h.01
| Columbus Crew | Los Angeles Galaxy | 23/4 01:30 |
| New York City | Cincinnati | 23/4 01:30 |
| New York Red Bulls | DC United | 23/4 01:30 |
| Orlando City | Charlotte | 23/4 01:30 |
| Toronto FC | Philadelphia Union | 23/4 01:30 |
| Atlanta Utd | New England Revolution | 23/4 01:45 |
| FC Dallas | Minnesota | 23/4 02:30 |
| Houston Dynamo | San Diego FC | 23/4 02:30 |
| Real Salt Lake | Inter Miami | 23/4 03:30 |
| Los Angeles FC | Colorado Rapids | 23/4 04:30 |
| San Jose Earthquakes | Austin FC | 23/4 04:30 |
| CF Montreal | Toronto FC | 17/7 01:30 |
| St. Louis City | Sporting Kansas City | 17/7 02:30 |
| Chicago Fire | Vancouver Whitecaps | 17/7 02:30 |
| Seattle Sounders | Portland Timbers | 17/7 04:30 |
|
Day 10 - Scadenza: 25/4, h.19
| Toronto FC | Atlanta Utd | 25/4 19:00 |
| CF Montreal | New York City | 25/4 20:30 |
| Minnesota | Los Angeles FC | 25/4 22:45 |
| Cincinnati | New York Red Bulls | 26/4 01:30 |
| Columbus Crew | Philadelphia Union | 26/4 01:30 |
| DC United | Orlando City | 26/4 01:30 |
| Inter Miami | New England Revolution | 26/4 01:30 |
| Austin FC | Houston Dynamo | 26/4 02:30 |
| Chicago Fire | Sporting Kansas City | 26/4 02:30 |
| Nashville SC | Charlotte | 26/4 02:30 |
| St. Louis City | San Jose Earthquakes | 26/4 02:30 |
| San Diego FC | Portland Timbers | 26/4 03:30 |
| Seattle Sounders | FC Dallas | 26/4 04:30 |
| Vancouver Whitecaps | Colorado Rapids | 26/4 04:30 |
| Los Angeles Galaxy | Real Salt Lake | 27/4 01:00 |
|
Day 11 - Scadenza: 2/5, h.19
| Toronto FC | San Jose Earthquakes | 2/5 19:00 |
| Sporting Kansas City | Seattle Sounders | 2/5 20:30 |
| Real Salt Lake | Portland Timbers | 2/5 22:30 |
| Inter Miami | Orlando City | 3/5 01:00 |
| Columbus Crew | Minnesota | 3/5 01:30 |
| New England Revolution | Charlotte | 3/5 01:30 |
| New York Red Bulls | FC Dallas | 3/5 01:30 |
| Philadelphia Union | Nashville SC | 3/5 01:30 |
| Atlanta Utd | CF Montreal | 3/5 01:30 |
| Chicago Fire | Cincinnati | 3/5 02:30 |
| Houston Dynamo | Colorado Rapids | 3/5 02:30 |
| San Diego FC | Los Angeles FC | 3/5 03:30 |
| Los Angeles Galaxy | Vancouver Whitecaps | 3/5 04:30 |
| New York City | DC United | 3/5 21:00 |
| Austin FC | St. Louis City | 3/5 23:30 |
|
Day 12 - Scadenza: 9/5, h.19
| Toronto FC | Inter Miami | 9/5 19:00 |
| Chicago Fire | New York Red Bulls | 9/5 20:30 |
| CF Montreal | Orlando City | 9/5 22:30 |
| Atlanta Utd | Los Angeles Galaxy | 10/5 01:30 |
| Charlotte | Cincinnati | 10/5 01:30 |
| New England Revolution | Philadelphia Union | 10/5 01:30 |
| FC Dallas | Real Salt Lake | 10/5 02:30 |
| Nashville SC | DC United | 10/5 03:15 |
| Colorado Rapids | St. Louis City | 10/5 03:30 |
| Portland Timbers | Sporting Kansas City | 10/5 04:30 |
| Seattle Sounders | San Diego FC | 10/5 04:30 |
| San Jose Earthquakes | Vancouver Whitecaps | 10/5 04:30 |
| New York City | Columbus Crew | 10/5 22:30 |
| Minnesota | Austin FC | 11/5 01:00 |
| Los Angeles FC | Houston Dynamo | 11/5 03:00 |
|
Day 13 - Scadenza: 14/5, h.01
| Charlotte | New York City | 14/5 01:15 |
| Cincinnati | Inter Miami | 14/5 01:30 |
| DC United | Chicago Fire | 14/5 01:30 |
| New England Revolution | Nashville SC | 14/5 01:30 |
| New York Red Bulls | Columbus Crew | 14/5 01:30 |
| Orlando City | Philadelphia Union | 14/5 01:30 |
| CF Montreal | Portland Timbers | 14/5 01:30 |
| Sporting Kansas City | Los Angeles Galaxy | 14/5 02:30 |
| Minnesota | Colorado Rapids | 14/5 02:30 |
| St. Louis City | Los Angeles FC | 14/5 02:30 |
| FC Dallas | Vancouver Whitecaps | 14/5 02:30 |
| Real Salt Lake | Houston Dynamo | 14/5 03:30 |
| San Diego FC | Austin FC | 14/5 03:30 |
| Seattle Sounders | San Jose Earthquakes | 14/5 03:30 |
| Nashville SC | Atlanta Utd | 18/7 02:15 |
|
Day 14 - Scadenza: 16/5, h.22
| CF Montreal | Chicago Fire | 16/5 22:30 |
| DC United | St. Louis City | 17/5 01:30 |
| New England Revolution | Minnesota | 17/5 01:30 |
| New York Red Bulls | New York City | 17/5 01:30 |
| Orlando City | Atlanta Utd | 17/5 01:30 |
| Philadelphia Union | Columbus Crew | 17/5 01:30 |
| Charlotte | Toronto FC | 17/5 01:30 |
| Austin FC | Sporting Kansas City | 17/5 02:30 |
| Houston Dynamo | Vancouver Whitecaps | 17/5 02:30 |
| Seattle Sounders | Los Angeles Galaxy | 17/5 03:15 |
| Real Salt Lake | Colorado Rapids | 17/5 03:30 |
| San Diego FC | Cincinnati | 17/5 03:30 |
| San Jose Earthquakes | FC Dallas | 17/5 04:30 |
| Inter Miami | Portland Timbers | 18/5 00:00 |
| Nashville SC | Los Angeles FC | 18/5 02:00 |
|
Day 15 - Scadenza: 23/5, h.20
| St. Louis City | Austin FC | 23/5 20:45 |
| Charlotte | New England Revolution | 24/5 01:30 |
| Cincinnati | Orlando City | 24/5 01:30 |
| DC United | CF Montreal | 24/5 01:30 |
| Sporting Kansas City | New York Red Bulls | 24/5 02:30 |
| Minnesota | Real Salt Lake | 24/5 02:30 |
| Nashville SC | New York City | 24/5 02:30 |
| Chicago Fire | Toronto FC | 24/5 02:30 |
| Colorado Rapids | FC Dallas | 24/5 03:30 |
| Portland Timbers | San Jose Earthquakes | 24/5 03:30 |
| San Diego FC | Vancouver Whitecaps | 24/5 03:30 |
| Los Angeles Galaxy | Houston Dynamo | 24/5 04:30 |
| Columbus Crew | Atlanta Utd | 24/5 23:00 |
| Inter Miami | Philadelphia Union | 25/5 01:15 |
| Los Angeles FC | Seattle Sounders | 25/5 03:00 |
|
Day 16 - Scadenza: 23/7, h.01
| Columbus Crew | New York City | 23/7 01:30 |
| Inter Miami | Chicago Fire | 23/7 01:30 |
| Philadelphia Union | New York Red Bulls | 23/7 01:30 |
| Cincinnati | Vancouver Whitecaps | 23/7 01:30 |
| New England Revolution | Toronto FC | 23/7 01:30 |
| Charlotte | Atlanta Utd | 23/7 02:00 |
| Austin FC | Seattle Sounders | 23/7 02:30 |
| Houston Dynamo | DC United | 23/7 02:30 |
| Sporting Kansas City | Minnesota | 23/7 02:30 |
| Nashville SC | CF Montreal | 23/7 02:30 |
| Colorado Rapids | San Diego FC | 23/7 03:30 |
| Los Angeles Galaxy | St. Louis City | 23/7 04:30 |
| Los Angeles FC | Real Salt Lake | 23/7 04:30 |
| Portland Timbers | FC Dallas | 23/7 04:30 |
| San Jose Earthquakes | Orlando City | 23/7 04:30 |
|
Day 17 - Scadenza: 26/7, h.01
| Columbus Crew | Cincinnati | 26/7 01:15 |
| New England Revolution | Atlanta Utd | 26/7 01:30 |
| New York City | Chicago Fire | 26/7 01:30 |
| New York Red Bulls | Charlotte | 26/7 01:30 |
| Orlando City | Nashville SC | 26/7 01:30 |
| Philadelphia Union | Seattle Sounders | 26/7 01:30 |
| DC United | Toronto FC | 26/7 01:30 |
| CF Montreal | Inter Miami | 26/7 01:30 |
| Houston Dynamo | Austin FC | 26/7 02:30 |
| St. Louis City | Colorado Rapids | 26/7 02:30 |
| Minnesota | Vancouver Whitecaps | 26/7 02:30 |
| San Diego FC | FC Dallas | 26/7 03:30 |
| Los Angeles FC | Sporting Kansas City | 26/7 04:30 |
| Portland Timbers | Real Salt Lake | 26/7 04:30 |
| San Jose Earthquakes | Los Angeles Galaxy | 26/7 04:30 |
|
Day 18 - Scadenza: 1/8, h.01
| New York City | Toronto FC | 1/8 01:30 |
| Cincinnati | San Jose Earthquakes | 2/8 01:30 |
| DC United | Nashville SC | 2/8 01:30 |
| Inter Miami | Columbus Crew | 2/8 01:30 |
| New York Red Bulls | Orlando City | 2/8 01:30 |
| Philadelphia Union | Atlanta Utd | 2/8 01:30 |
| CF Montreal | New England Revolution | 2/8 01:30 |
| Vancouver Whitecaps | Los Angeles FC | 2/8 01:30 |
| Chicago Fire | Charlotte | 2/8 02:30 |
| Sporting Kansas City | Houston Dynamo | 2/8 02:30 |
| Minnesota | San Diego FC | 2/8 02:30 |
| St. Louis City | Real Salt Lake | 2/8 02:30 |
| Colorado Rapids | Austin FC | 2/8 03:30 |
| Los Angeles Galaxy | FC Dallas | 2/8 04:30 |
| Portland Timbers | Seattle Sounders | 2/8 04:45 |
|
Day 19 - Scadenza: 16/8, h.01
| Atlanta Utd | New York Red Bulls | 16/8 01:30 |
| Charlotte | Columbus Crew | 16/8 01:30 |
| Orlando City | Cincinnati | 16/8 01:30 |
| CF Montreal | DC United | 16/8 01:30 |
| Toronto FC | New England Revolution | 16/8 01:30 |
| Austin FC | FC Dallas | 16/8 02:30 |
| Houston Dynamo | Los Angeles Galaxy | 16/8 02:30 |
| Nashville SC | Inter Miami | 16/8 02:30 |
| Colorado Rapids | Sporting Kansas City | 16/8 03:30 |
| Real Salt Lake | Minnesota | 16/8 03:30 |
| Los Angeles FC | San Diego FC | 16/8 04:30 |
| San Jose Earthquakes | St. Louis City | 16/8 04:30 |
| Chicago Fire | Portland Timbers | 17/8 00:30 |
| New York City | Philadelphia Union | 17/8 00:30 |
| Seattle Sounders | Vancouver Whitecaps | 17/8 03:00 |
|
Day 20 - Scadenza: 20/8, h.01
| Cincinnati | New York City | 20/8 01:30 |
| DC United | New England Revolution | 20/8 01:30 |
| New York Red Bulls | Nashville SC | 20/8 01:30 |
| Orlando City | Chicago Fire | 20/8 01:30 |
| Philadelphia Union | Inter Miami | 20/8 01:30 |
| Columbus Crew | CF Montreal | 20/8 01:30 |
| Toronto FC | Charlotte | 20/8 01:30 |
| Sporting Kansas City | St. Louis City | 20/8 02:00 |
| Minnesota | Atlanta Utd | 20/8 02:30 |
| Colorado Rapids | Los Angeles FC | 20/8 03:30 |
| Real Salt Lake | FC Dallas | 20/8 03:30 |
| Seattle Sounders | Austin FC | 20/8 03:30 |
| Los Angeles Galaxy | San Jose Earthquakes | 20/8 04:30 |
| Portland Timbers | San Diego FC | 20/8 04:30 |
| Vancouver Whitecaps | Houston Dynamo | 20/8 04:30 |
|
Day 21 - Scadenza: 23/8, h.01
| Charlotte | DC United | 23/8 01:30 |
| Cincinnati | Seattle Sounders | 23/8 01:30 |
| New York Red Bulls | Chicago Fire | 23/8 01:30 |
| Orlando City | Real Salt Lake | 23/8 01:30 |
| Inter Miami | Toronto FC | 23/8 01:30 |
| CF Montreal | Los Angeles Galaxy | 23/8 01:30 |
| Austin FC | Philadelphia Union | 23/8 02:30 |
| Nashville SC | Columbus Crew | 23/8 02:30 |
| St. Louis City | Houston Dynamo | 23/8 02:30 |
| Vancouver Whitecaps | FC Dallas | 23/8 03:30 |
| Los Angeles FC | Portland Timbers | 23/8 04:30 |
| San Diego FC | Colorado Rapids | 23/8 04:30 |
| San Jose Earthquakes | Minnesota | 23/8 04:30 |
| New England Revolution | New York City | 23/8 22:30 |
| Atlanta Utd | Sporting Kansas City | 24/8 01:00 |
|
Day 22 - Scadenza: 29/8, h.22
| Seattle Sounders | Chicago Fire | 29/8 22:30 |
| Atlanta Utd | Charlotte | 30/8 01:30 |
| Columbus Crew | New England Revolution | 30/8 01:30 |
| DC United | Los Angeles FC | 30/8 01:30 |
| New York Red Bulls | Philadelphia Union | 30/8 01:30 |
| Inter Miami | CF Montreal | 30/8 01:30 |
| Toronto FC | New York City | 30/8 01:30 |
| Houston Dynamo | San Jose Earthquakes | 30/8 02:30 |
| Minnesota | Orlando City | 30/8 02:30 |
| Nashville SC | Cincinnati | 30/8 02:30 |
| Sporting Kansas City | Vancouver Whitecaps | 30/8 02:30 |
| Colorado Rapids | Real Salt Lake | 30/8 03:30 |
| Portland Timbers | Austin FC | 30/8 04:30 |
| San Diego FC | Los Angeles Galaxy | 30/8 04:30 |
| St. Louis City | FC Dallas | 31/8 01:00 |
|
Day 23 - Scadenza: 5/9, h.01
| New York City | Nashville SC | 5/9 01:30 |
| Charlotte | Houston Dynamo | 6/9 01:30 |
| Cincinnati | DC United | 6/9 01:30 |
| Columbus Crew | Colorado Rapids | 6/9 01:30 |
| Inter Miami | Atlanta Utd | 6/9 01:30 |
| Orlando City | San Diego FC | 6/9 01:30 |
| Philadelphia Union | CF Montreal | 6/9 01:30 |
| Toronto FC | Chicago Fire | 6/9 01:30 |
| Austin FC | San Jose Earthquakes | 6/9 02:30 |
| FC Dallas | Sporting Kansas City | 6/9 02:30 |
| Seattle Sounders | New York Red Bulls | 6/9 02:30 |
| Los Angeles Galaxy | New England Revolution | 6/9 03:30 |
| Real Salt Lake | Los Angeles FC | 6/9 03:30 |
| Portland Timbers | Minnesota | 6/9 04:30 |
| Vancouver Whitecaps | St. Louis City | 6/9 04:30 |
|
Day 24 - Scadenza: 10/9, h.01
| Atlanta Utd | Orlando City | 10/9 01:30 |
| DC United | Columbus Crew | 10/9 01:30 |
| New York City | New England Revolution | 10/9 01:30 |
| CF Montreal | Charlotte | 10/9 01:30 |
| Toronto FC | Nashville SC | 10/9 01:30 |
| Philadelphia Union | Cincinnati | 10/9 01:45 |
| Austin FC | Colorado Rapids | 10/9 02:30 |
| Chicago Fire | Inter Miami | 10/9 02:30 |
| Houston Dynamo | Real Salt Lake | 10/9 02:30 |
| Minnesota | FC Dallas | 10/9 02:30 |
| Los Angeles FC | New York Red Bulls | 10/9 04:30 |
| Portland Timbers | St. Louis City | 10/9 04:30 |
| San Diego FC | San Jose Earthquakes | 10/9 04:30 |
| Seattle Sounders | Sporting Kansas City | 10/9 04:30 |
| Vancouver Whitecaps | Los Angeles Galaxy | 10/9 04:30 |
|
Day 25 - Scadenza: 13/9, h.01
| Cincinnati | Charlotte | 13/9 01:30 |
| Columbus Crew | New York Red Bulls | 13/9 01:30 |
| DC United | Atlanta Utd | 13/9 01:30 |
| Inter Miami | Nashville SC | 13/9 01:30 |
| Orlando City | Toronto FC | 13/9 01:30 |
| FC Dallas | Portland Timbers | 13/9 02:30 |
| Sporting Kansas City | Los Angeles FC | 13/9 02:30 |
| St. Louis City | Minnesota | 13/9 02:30 |
| Real Salt Lake | New York City | 13/9 03:30 |
| Colorado Rapids | CF Montreal | 13/9 03:30 |
| Los Angeles Galaxy | Seattle Sounders | 13/9 04:30 |
| San Jose Earthquakes | Houston Dynamo | 13/9 04:30 |
| Chicago Fire | New England Revolution | 14/9 00:30 |
| Vancouver Whitecaps | Austin FC | 14/9 00:30 |
| San Diego FC | Philadelphia Union | 14/9 03:00 |
|
Day 26 - Scadenza: 19/9, h.01
| New York City | New York Red Bulls | 19/9 01:30 |
| DC United | Charlotte | 20/9 01:30 |
| New England Revolution | Orlando City | 20/9 01:30 |
| San Jose Earthquakes | Los Angeles FC | 20/9 01:30 |
| CF Montreal | Columbus Crew | 20/9 01:30 |
| FC Dallas | Austin FC | 20/9 02:30 |
| Houston Dynamo | Cincinnati | 20/9 02:30 |
| Sporting Kansas City | Philadelphia Union | 20/9 02:30 |
| Minnesota | Los Angeles Galaxy | 20/9 02:30 |
| St. Louis City | Toronto FC | 20/9 02:30 |
| Colorado Rapids | Seattle Sounders | 20/9 03:30 |
| Nashville SC | Chicago Fire | 20/9 03:30 |
| Real Salt Lake | Vancouver Whitecaps | 20/9 03:30 |
| Portland Timbers | Atlanta Utd | 20/9 04:30 |
| Inter Miami | San Diego FC | 21/9 01:00 |
|
Day 27 - Scadenza: 27/9, h.01
| Atlanta Utd | New York City | 27/9 01:30 |
| Charlotte | Chicago Fire | 27/9 01:30 |
| New York Red Bulls | St. Louis City | 27/9 01:30 |
| Philadelphia Union | Orlando City | 27/9 01:30 |
| CF Montreal | Cincinnati | 27/9 01:30 |
| Austin FC | San Diego FC | 27/9 02:30 |
| FC Dallas | Los Angeles FC | 27/9 02:30 |
| Houston Dynamo | Sporting Kansas City | 27/9 02:30 |
| Seattle Sounders | Minnesota | 27/9 02:30 |
| Nashville SC | Toronto FC | 27/9 02:30 |
| Real Salt Lake | New England Revolution | 27/9 03:30 |
| Los Angeles Galaxy | Colorado Rapids | 27/9 04:30 |
| San Jose Earthquakes | Portland Timbers | 27/9 04:30 |
| Vancouver Whitecaps | DC United | 27/9 04:30 |
| Columbus Crew | Inter Miami | 28/9 01:00 |
|
Day 28 - Scadenza: 10/10, h.19
| Toronto FC | CF Montreal | 10/10 19:00 |
| Chicago Fire | New York City | 10/10 20:30 |
| Atlanta Utd | Cincinnati | 11/10 01:30 |
| Charlotte | FC Dallas | 11/10 01:30 |
| Inter Miami | DC United | 11/10 01:30 |
| New England Revolution | Seattle Sounders | 11/10 01:30 |
| New York Red Bulls | San Diego FC | 11/10 01:30 |
| Orlando City | Columbus Crew | 11/10 01:30 |
| Philadelphia Union | Real Salt Lake | 11/10 01:30 |
| Austin FC | Nashville SC | 11/10 02:30 |
| Sporting Kansas City | Portland Timbers | 11/10 02:30 |
| Minnesota | Houston Dynamo | 11/10 02:30 |
| Colorado Rapids | San Jose Earthquakes | 11/10 03:30 |
| Los Angeles FC | Vancouver Whitecaps | 11/10 04:30 |
| St. Louis City | Los Angeles Galaxy | 12/10 01:00 |
|
Day 29 - Scadenza: 15/10, h.01
| Cincinnati | New England Revolution | 15/10 01:30 |
| Columbus Crew | Charlotte | 15/10 01:30 |
| DC United | New York Red Bulls | 15/10 01:30 |
| Inter Miami | New York City | 15/10 01:30 |
| CF Montreal | Atlanta Utd | 15/10 01:30 |
| Toronto FC | Orlando City | 15/10 01:30 |
| Chicago Fire | Philadelphia Union | 15/10 02:30 |
| FC Dallas | Seattle Sounders | 15/10 02:30 |
| Nashville SC | Sporting Kansas City | 15/10 02:30 |
| St. Louis City | Vancouver Whitecaps | 15/10 02:30 |
| Colorado Rapids | Minnesota | 15/10 03:30 |
| Real Salt Lake | San Jose Earthquakes | 15/10 03:30 |
| Los Angeles Galaxy | Portland Timbers | 15/10 04:30 |
| Los Angeles FC | Austin FC | 15/10 04:30 |
| San Diego FC | Houston Dynamo | 15/10 04:30 |
|
Day 30 - Scadenza: 17/10, h.20
| Philadelphia Union | Charlotte | 17/10 20:30 |
| Minnesota | St. Louis City | 17/10 22:30 |
| Atlanta Utd | Inter Miami | 18/10 01:30 |
| New England Revolution | Chicago Fire | 18/10 01:30 |
| Orlando City | DC United | 18/10 01:30 |
| New York Red Bulls | Toronto FC | 18/10 01:30 |
| Houston Dynamo | FC Dallas | 18/10 02:30 |
| Sporting Kansas City | Real Salt Lake | 18/10 02:30 |
| Austin FC | Vancouver Whitecaps | 18/10 02:30 |
| Los Angeles Galaxy | San Diego FC | 18/10 04:30 |
| Portland Timbers | Colorado Rapids | 18/10 04:30 |
| San Jose Earthquakes | Nashville SC | 18/10 04:30 |
| Seattle Sounders | CF Montreal | 18/10 04:30 |
| Cincinnati | Columbus Crew | 19/10 01:00 |
|
Day 31 - Scadenza: 24/10, h.19
| CF Montreal | Nashville SC | 24/10 19:30 |
| Columbus Crew | Toronto FC | 24/10 20:30 |
| New York Red Bulls | Inter Miami | 24/10 22:30 |
| Atlanta Utd | Chicago Fire | 25/10 01:30 |
| DC United | Cincinnati | 25/10 01:30 |
| Orlando City | New York City | 25/10 01:30 |
| Philadelphia Union | New England Revolution | 25/10 01:30 |
| FC Dallas | San Jose Earthquakes | 25/10 02:30 |
| Houston Dynamo | Minnesota | 25/10 02:30 |
| Sporting Kansas City | Austin FC | 25/10 02:30 |
| Real Salt Lake | St. Louis City | 25/10 02:30 |
| Colorado Rapids | Vancouver Whitecaps | 25/10 02:30 |
| Portland Timbers | Charlotte | 25/10 03:30 |
| San Diego FC | Seattle Sounders | 25/10 03:30 |
| Los Angeles FC | Los Angeles Galaxy | 26/10 02:00 |
|
Day 32 - Scadenza: 29/10, h.00
| Inter Miami | Cincinnati | 29/10 00:30 |
| New England Revolution | New York Red Bulls | 29/10 00:30 |
| New York City | Atlanta Utd | 29/10 00:30 |
| Charlotte | CF Montreal | 29/10 00:30 |
| Toronto FC | DC United | 29/10 00:30 |
| Austin FC | Real Salt Lake | 29/10 01:30 |
| Chicago Fire | Orlando City | 29/10 01:30 |
| FC Dallas | Columbus Crew | 29/10 01:30 |
| Minnesota | Sporting Kansas City | 29/10 01:30 |
| Nashville SC | Philadelphia Union | 29/10 01:30 |
| St. Louis City | Portland Timbers | 29/10 01:30 |
| San Jose Earthquakes | Colorado Rapids | 29/10 03:30 |
| Seattle Sounders | Houston Dynamo | 29/10 03:30 |
| Vancouver Whitecaps | San Diego FC | 29/10 03:30 |
|
Day 33 - Scadenza: 31/10, h.18
| Charlotte | Orlando City | 31/10 18:00 |
| Cincinnati | Philadelphia Union | 31/10 19:00 |
| Columbus Crew | DC United | 31/10 19:00 |
| New York City | CF Montreal | 31/10 19:00 |
| Sporting Kansas City | FC Dallas | 31/10 20:00 |
| St. Louis City | San Diego FC | 31/10 20:00 |
| Los Angeles Galaxy | Austin FC | 31/10 22:00 |
| Colorado Rapids | Chicago Fire | 1/11 02:30 |
| San Jose Earthquakes | Real Salt Lake | 1/11 03:30 |
| Nashville SC | New York Red Bulls | 1/11 22:30 |
| Los Angeles FC | Minnesota | 1/11 22:30 |
| Vancouver Whitecaps | Seattle Sounders | 1/11 22:30 |
| Atlanta Utd | Toronto FC | 1/11 22:30 |
| New England Revolution | Inter Miami | 2/11 01:00 |
| Portland Timbers | Houston Dynamo | 2/11 03:15 |
|
Day 34 - Scadenza: 7/11, h.22
| Chicago Fire | Columbus Crew | 7/11 22:00 |
| Cincinnati | Nashville SC | 7/11 22:00 |
| DC United | New York City | 7/11 22:00 |
| Inter Miami | Charlotte | 7/11 22:00 |
| New York Red Bulls | Atlanta Utd | 7/11 22:00 |
| Orlando City | New England Revolution | 7/11 22:00 |
| CF Montreal | Vancouver Whitecaps | 7/11 22:00 |
| Philadelphia Union | Toronto FC | 7/11 22:00 |
| Austin FC | Portland Timbers | 8/11 01:00 |
| FC Dallas | Colorado Rapids | 8/11 01:00 |
| Houston Dynamo | St. Louis City | 8/11 01:00 |
| Minnesota | San Jose Earthquakes | 8/11 01:00 |
| Real Salt Lake | Los Angeles Galaxy | 8/11 01:00 |
| San Diego FC | Sporting Kansas City | 8/11 01:00 |
| Seattle Sounders | Los Angeles FC | 8/11 01:00 |
|
Round One - Game 1 - Scadenza: 11/11, h.02| Partite non impostate |
|
Round One - Game 2 - Scadenza: 14/11, h.20| Partite non impostate |
|
Round One - Game 3 - Scadenza: 17/11, h.01| Partite non impostate |
|
Conference Semifinals - Scadenza: 20/11, h.03| Partite non impostate |
|
Conference Finals - Scadenza: 23/11, h.00| Partite non impostate |
|
MLS CUP - Scadenza: 26/11, h.20| Partite non impostate |
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