L'orario della scadenza è relativo alla prima partita in programma.
Fra parentesi il numero di utenti che hanno scelto la squadra.
Day 1 - Scadenza: 21/2, h.20
| St. Louis City (2) | Charlotte (1) | 1-1 |
| Cincinnati (4) | Atlanta Utd (1) | 2-0 |
| DC United (2) | Philadelphia Union (5) | 1-0 |
| Orlando City | New York Red Bulls | 1-2 |
| Vancouver Whitecaps (12) | Real Salt Lake | 1-0 |
| Austin FC | Minnesota (1) | 2-2 |
| Houston Dynamo (2) | Chicago Fire | 2-1 |
| Nashville SC (2) | New England Revolution | 4-1 |
| FC Dallas (2) | Toronto FC | 3-2 |
| Los Angeles FC (1) | Inter Miami (1) | 3-0 |
| Portland Timbers | Columbus Crew (1) | 3-2 |
| San Jose Earthquakes | Sporting Kansas City | 3-0 |
| San Diego FC (24) | CF Montreal | 5-0 |
| Los Angeles Galaxy (4) | New York City (1) | 1-1 |
| Seattle Sounders (12) | Colorado Rapids | 2-0 |
|
Day 2 - Scadenza: 28/2, h.20
| New York Red Bulls (1) | New England Revolution | 1-0 |
| Chicago Fire (6) | CF Montreal | 3-0 |
| Colorado Rapids | Portland Timbers (8) | 2-0 |
| Minnesota | Cincinnati (1) | 1-0 |
| Real Salt Lake | Seattle Sounders (7) | 2-1 |
| San Jose Earthquakes (1) | Atlanta Utd (1) | 2-0 |
| FC Dallas | Nashville SC (3) | 0-0 |
| Houston Dynamo | Los Angeles FC (9) | 0-2 |
| Sporting Kansas City | Columbus Crew (35) | 2-2 |
| Vancouver Whitecaps (3) | Toronto FC | 3-0 |
| Los Angeles Galaxy | Charlotte | 3-0 |
| Austin FC | DC United (1) | 1-0 |
| Philadelphia Union | New York City | 1-2 |
| Orlando City | Inter Miami (3) | 2-4 |
| San Diego FC (1) | St. Louis City | 2-0 |
|
Day 3 - Scadenza: 7/3, h.20
| New York City (6) | Orlando City | 5-0 |
| DC United | Inter Miami (1) | 1-2 |
| Atlanta Utd | Real Salt Lake (4) | 2-3 |
| Charlotte | Austin FC | 3-1 |
| Columbus Crew | Chicago Fire (1) | 0-0 |
| Philadelphia Union (1) | San Jose Earthquakes | 0-1 |
| Sporting Kansas City | San Diego FC (6) | 0-1 |
| Nashville SC | Minnesota | 3-1 |
| St. Louis City | Seattle Sounders | 0-1 |
| Colorado Rapids | Los Angeles Galaxy | 4-1 |
| Los Angeles FC (19) | FC Dallas | 1-0 |
| Portland Timbers | Vancouver Whitecaps (1) | 1-4 |
| New York Red Bulls (41) | CF Montreal | 0-3 |
| Cincinnati (1) | Toronto FC | 0-1 |
| New England Revolution | Houston Dynamo | 0-2 |
|
Day 4 - Scadenza: 14/3, h.18
| Toronto FC | New York Red Bulls (3) | 1-1 |
| Atlanta Utd | Philadelphia Union (2) | 3-1 |
| Columbus Crew | Nashville SC (6) | 0-1 |
| Charlotte | Inter Miami (24) | 0-0 |
| New York City | Colorado Rapids | 3-1 |
| Orlando City | CF Montreal (8) | 2-1 |
| Chicago Fire | DC United | 1-2 |
| FC Dallas | San Diego FC (17) | 3-3 |
| Houston Dynamo | Portland Timbers | 3-2 |
| Los Angeles Galaxy (4) | Sporting Kansas City | 1-2 |
| Real Salt Lake | Austin FC (1) | 2-1 |
| Los Angeles FC (7) | St. Louis City | 2-0 |
| New England Revolution | Cincinnati (4) | 6-1 |
| Vancouver Whitecaps (2) | Minnesota | 6-0 |
| San Jose Earthquakes | Seattle Sounders | 0-1 |
|
Day 5 - Scadenza: 21/3, h.18
| Toronto FC (15) | Columbus Crew (1) | 2-1 |
| Philadelphia Union | Chicago Fire (4) | 1-2 |
| Nashville SC (38) | Orlando City | 5-0 |
| Atlanta Utd | DC United | 0-0 |
| Charlotte (2) | New York Red Bulls | 6-1 |
| FC Dallas | Houston Dynamo | 4-3 |
| Sporting Kansas City | Colorado Rapids | 1-4 |
| St. Louis City | New England Revolution | 3-1 |
| Austin FC | Los Angeles FC (7) | 0-0 |
| Vancouver Whitecaps (8) | San Jose Earthquakes | 0-1 |
| New York City | Inter Miami | 2-3 |
| Cincinnati (1) | CF Montreal | 4-3 |
| Minnesota | Seattle Sounders | 0-0 |
| Portland Timbers | Los Angeles Galaxy | 1-1 |
| San Diego FC (2) | Real Salt Lake | 2-2 |
|
Day 6 - Scadenza: 4/4, h.19
| Toronto FC | Colorado Rapids (2) | 3-2 |
| Real Salt Lake (2) | Sporting Kansas City | 3-1 |
| New England Revolution | CF Montreal | 3-0 |
| Atlanta Utd (1) | Columbus Crew (2) | 1-3 |
| Charlotte (5) | Philadelphia Union | 2-1 |
| DC United | FC Dallas (3) | 0-4 |
| Inter Miami (3) | Austin FC | 2-2 |
| New York City | St. Louis City | 1-1 |
| New York Red Bulls | Cincinnati | 4-2 |
| Chicago Fire | Nashville SC (22) | 1-0 |
| Houston Dynamo | Seattle Sounders (36) | 0-1 |
| Los Angeles FC | Orlando City | 6-0 |
| Los Angeles Galaxy | Minnesota (1) | 1-2 |
| San Jose Earthquakes | San Diego FC (1) | 3-0 |
| Vancouver Whitecaps (2) | Portland Timbers | 3-2 |
|
Day 7 - Scadenza: 11/4, h.19
| Toronto FC | Cincinnati | 1-1 |
| Austin FC | Los Angeles Galaxy | 1-2 |
| CF Montreal (15) | Philadelphia Union (1) | 1-2 |
| Portland Timbers | Los Angeles FC (1) | 2-1 |
| Charlotte | Nashville SC | 1-2 |
| Inter Miami (11) | New York Red Bulls | 2-2 |
| New England Revolution (2) | DC United | 1-0 |
| Vancouver Whitecaps (3) | New York City | 2-0 |
| Chicago Fire (17) | Atlanta Utd | 1-0 |
| FC Dallas (4) | St. Louis City | 1-1 |
| Sporting Kansas City (1) | San Jose Earthquakes (10) | 1-3 |
| Colorado Rapids (1) | Houston Dynamo | 6-2 |
| San Diego FC | Minnesota | 1-2 |
| Columbus Crew (10) | Orlando City | 1-1 |
| Seattle Sounders (1) | Real Salt Lake | 13/4 03:00 |
|
Day 8 - Scadenza: 18/4, h.04
| Vancouver Whitecaps (6) | Sporting Kansas City | 3-0 |
| Toronto FC | Austin FC | 3-3 |
| CF Montreal | New York Red Bulls (31) | 4-1 |
| Colorado Rapids | Inter Miami (5) | 2-3 |
| Atlanta Utd | Nashville SC (19) | 0-2 |
| Cincinnati | Chicago Fire (8) | 3-3 |
| New England Revolution | Columbus Crew | 2-1 |
| New York City | Charlotte | 1-2 |
| Orlando City | Houston Dynamo (2) | 0-1 |
| Philadelphia Union (1) | DC United (1) | 0-0 |
| FC Dallas (1) | Los Angeles Galaxy | 2-2 |
| Minnesota (1) | Portland Timbers | 2-0 |
| Real Salt Lake | San Diego FC | 4-2 |
| Seattle Sounders (5) | St. Louis City | 4-1 |
| Los Angeles FC | San Jose Earthquakes (1) | 1-4 |
|
Day 9 - Scadenza: 23/4, h.01
| Columbus Crew | Los Angeles Galaxy | 2-1 |
| New York City (1) | Cincinnati | 4-4 |
| New York Red Bulls (1) | DC United | 4-4 |
| Orlando City | Charlotte (9) | 4-1 |
| Toronto FC (14) | Philadelphia Union | 3-3 |
| Atlanta Utd | New England Revolution (3) | 1-2 |
| FC Dallas | Minnesota | 0-1 |
| Houston Dynamo (1) | San Diego FC | 1-0 |
| Real Salt Lake | Inter Miami | 0-2 |
| Los Angeles FC (6) | Colorado Rapids | 0-0 |
| San Jose Earthquakes (31) | Austin FC | 5-1 |
| CF Montreal (1) | Toronto FC (1) | 0-0 |
| St. Louis City (4) | Sporting Kansas City | 3-2 |
| Chicago Fire (2) | Vancouver Whitecaps | 17/7 02:30 |
| Seattle Sounders (2) | Portland Timbers | 1-5 |
|
Day 10 - Scadenza: 25/4, h.19
| Toronto FC (2) | Atlanta Utd | 1-2 |
| CF Montreal | New York City (14) | 1-0 |
| Minnesota | Los Angeles FC (2) | 0-1 |
| Cincinnati | New York Red Bulls | 2-0 |
| Columbus Crew | Philadelphia Union | 2-0 |
| DC United | Orlando City (2) | 3-2 |
| Inter Miami (1) | New England Revolution | 1-1 |
| Austin FC | Houston Dynamo (1) | 2-0 |
| Chicago Fire (6) | Sporting Kansas City | 5-0 |
| Nashville SC (1) | Charlotte | 4-2 |
| St. Louis City | San Jose Earthquakes (43) | 2-3 |
| San Diego FC (1) | Portland Timbers | 1-2 |
| Seattle Sounders | FC Dallas | 2-1 |
| Vancouver Whitecaps | Colorado Rapids | 3-1 |
| Los Angeles Galaxy | Real Salt Lake (2) | 2-1 |
|
Day 11 - Scadenza: 2/5, h.19
| Toronto FC | San Jose Earthquakes | 1-1 |
| Sporting Kansas City | Seattle Sounders (11) | 1-1 |
| Real Salt Lake (11) | Portland Timbers | 2-0 |
| Inter Miami (40) | Orlando City | 3-4 |
| Columbus Crew | Minnesota | 2-3 |
| New England Revolution (2) | Charlotte | 1-0 |
| New York Red Bulls (2) | FC Dallas | 0-2 |
| Philadelphia Union | Nashville SC (2) | 0-0 |
| Atlanta Utd (3) | CF Montreal (1) | 3-1 |
| Chicago Fire (2) | Cincinnati | 2-3 |
| Houston Dynamo | Colorado Rapids | 1-0 |
| San Diego FC | Los Angeles FC | 2-2 |
| Los Angeles Galaxy | Vancouver Whitecaps | 1-1 |
| New York City (1) | DC United | 0-2 |
| Austin FC (4) | St. Louis City | 2-0 |
|
Day 12 - Scadenza: 9/5, h.19
| Toronto FC | Inter Miami (16) | 2-4 |
| Chicago Fire (1) | New York Red Bulls (1) | 1-3 |
| CF Montreal (1) | Orlando City (3) | 2-0 |
| Atlanta Utd | Los Angeles Galaxy (13) | 1-2 |
| Charlotte | Cincinnati (6) | 2-2 |
| New England Revolution (3) | Philadelphia Union (2) | 2-1 |
| FC Dallas | Real Salt Lake (2) | 3-1 |
| Nashville SC | DC United | 2-2 |
| Colorado Rapids (2) | St. Louis City | 0-1 |
| Portland Timbers (5) | Sporting Kansas City (2) | 6-0 |
| Seattle Sounders | San Diego FC | 1-1 |
| San Jose Earthquakes | Vancouver Whitecaps (14) | 1-1 |
| New York City | Columbus Crew | 3-0 |
| Minnesota | Austin FC | 2-2 |
| Los Angeles FC | Houston Dynamo (1) | 1-4 |
|
Day 13 - Scadenza: 14/5, h.01
| Charlotte | New York City | 0-1 |
| Cincinnati | Inter Miami | 3-5 |
| DC United (1) | Chicago Fire | 1-3 |
| New England Revolution | Nashville SC | 0-3 |
| New York Red Bulls (1) | Columbus Crew | 3-2 |
| Orlando City (13) | Philadelphia Union | 4-3 |
| CF Montreal (6) | Portland Timbers | 2-2 |
| Sporting Kansas City | Los Angeles Galaxy (11) | 3-1 |
| Minnesota (27) | Colorado Rapids | 0-1 |
| St. Louis City | Los Angeles FC (1) | 2-1 |
| FC Dallas | Vancouver Whitecaps (1) | 2-3 |
| Real Salt Lake (3) | Houston Dynamo | 3-0 |
| San Diego FC (3) | Austin FC | 5-0 |
| Seattle Sounders | San Jose Earthquakes | 3-2 |
| Nashville SC (10) | Atlanta Utd | 1-0 |
|
Day 14 - Scadenza: 16/5, h.22
| CF Montreal | Chicago Fire (25) | 0-2 |
| DC United (2) | St. Louis City (1) | 1-1 |
| New England Revolution | Minnesota | 2-1 |
| New York Red Bulls | New York City (2) | 1-1 |
| Orlando City | Atlanta Utd | 1-1 |
| Philadelphia Union | Columbus Crew (10) | 1-1 |
| Charlotte | Toronto FC (1) | 3-1 |
| Austin FC (3) | Sporting Kansas City | 1-2 |
| Houston Dynamo | Vancouver Whitecaps (22) | 1-0 |
| Seattle Sounders (1) | Los Angeles Galaxy (1) | 0-2 |
| Real Salt Lake | Colorado Rapids | 2-1 |
| San Diego FC | Cincinnati | 3-3 |
| San Jose Earthquakes (3) | FC Dallas | 2-3 |
| Inter Miami (4) | Portland Timbers | 2-0 |
| Nashville SC | Los Angeles FC | 3-2 |
|
Day 15 - Scadenza: 23/5, h.20
| St. Louis City (2) | Austin FC | 3-0 |
| Minnesota | Real Salt Lake (1) | 1-1 |
| Charlotte | New England Revolution | 1-0 |
| Cincinnati (4) | Orlando City | 6-2 |
| DC United (10) | CF Montreal | 4-4 |
| Sporting Kansas City (1) | New York Red Bulls (10) | 1-2 |
| Nashville SC (1) | New York City | 2-1 |
| Chicago Fire (17) | Toronto FC | 2-1 |
| Colorado Rapids | FC Dallas (1) | 1-2 |
| Portland Timbers (2) | San Jose Earthquakes | 1-3 |
| San Diego FC | Vancouver Whitecaps (1) | 2-4 |
| Los Angeles Galaxy (3) | Houston Dynamo | 1-1 |
| Columbus Crew (13) | Atlanta Utd | 2-0 |
| Inter Miami (9) | Philadelphia Union | 6-4 |
| Los Angeles FC | Seattle Sounders | 1-0 |
|
Day 16 - Scadenza: 23/7, h.01
| Columbus Crew | New York City | 1-2 |
| Inter Miami | Chicago Fire (1) | 3-2 |
| Philadelphia Union | New York Red Bulls (14) | 3-1 |
| Cincinnati | Vancouver Whitecaps (4) | 4-3 |
| New England Revolution | Toronto FC | 0-0 |
| Charlotte (2) | Atlanta Utd | 2-2 |
| Houston Dynamo | DC United | 1-1 |
| Sporting Kansas City | Minnesota (35) | 2-1 |
| Nashville SC (7) | CF Montreal | 1-0 |
| Austin FC | Seattle Sounders (2) | 3-1 |
| Colorado Rapids | San Diego FC | 1-0 |
| Los Angeles Galaxy | St. Louis City | 1-3 |
| Los Angeles FC (1) | Real Salt Lake (1) | 3-1 |
| Portland Timbers | FC Dallas (5) | 2-2 |
| San Jose Earthquakes (3) | Orlando City | 0-4 |
|
Day 17 - Scadenza: 26/7, h.00
| New York Red Bulls | Charlotte | 0-2 |
| Columbus Crew | Cincinnati (1) | 2-1 |
| New England Revolution (25) | Atlanta Utd | 4-1 |
| New York City | Chicago Fire | 3-1 |
| Orlando City | Nashville SC (4) | 1-0 |
| Philadelphia Union | Seattle Sounders (1) | 1-0 |
| DC United (1) | Toronto FC | 2-1 |
| CF Montreal | Inter Miami (4) | 0-1 |
| Houston Dynamo (15) | Austin FC | 3-0 |
| St. Louis City (2) | Colorado Rapids | 1-0 |
| Minnesota | Vancouver Whitecaps (1) | 0-0 |
| San Diego FC | FC Dallas (1) | 1-0 |
| Los Angeles FC (14) | Sporting Kansas City | 4-0 |
| Portland Timbers | Real Salt Lake | 2-1 |
| San Jose Earthquakes (4) | Los Angeles Galaxy | 1-1 |
|
Day 18 - Scadenza: 1/8, h.01
| New York City (5) | Toronto FC | 1-1 |
| Cincinnati (1) | San Jose Earthquakes (5) | 4-2 |
| DC United | Nashville SC (10) | 2-2 |
| Inter Miami | Columbus Crew | 2-2 |
| New York Red Bulls (1) | Orlando City (1) | 3-2 |
| Philadelphia Union (3) | Atlanta Utd (1) | 3-2 |
| CF Montreal | New England Revolution (10) | 2-2 |
| Vancouver Whitecaps | Los Angeles FC | 1-1 |
| Chicago Fire (2) | Charlotte | 2-1 |
| Sporting Kansas City | Houston Dynamo (36) | 0-2 |
| Minnesota | San Diego FC | 1-1 |
| St. Louis City | Real Salt Lake | 1-1 |
| Colorado Rapids (1) | Austin FC | 1-0 |
| Los Angeles Galaxy | FC Dallas | 0-0 |
| Portland Timbers | Seattle Sounders | 2-1 |
|
Day 19 - Scadenza: 16/8, h.01
| Atlanta Utd (1) | New York Red Bulls (4) | 2-1 |
| Charlotte (2) | Columbus Crew (1) | 3-1 |
| Orlando City | Cincinnati | 1-1 |
| CF Montreal | DC United | 1-1 |
| Toronto FC | New England Revolution | 2-1 |
| Houston Dynamo (2) | Los Angeles Galaxy | 1-0 |
| Nashville SC (1) | Inter Miami | 4-1 |
| Colorado Rapids (22) | Sporting Kansas City | 2-0 |
| Real Salt Lake | Minnesota | 1-1 |
| Los Angeles FC (21) | San Diego FC | 0-1 |
| San Jose Earthquakes | St. Louis City | 1-3 |
| Chicago Fire (3) | Portland Timbers | 2-1 |
| New York City (9) | Philadelphia Union | 2-3 |
| Austin FC | FC Dallas (4) | 1-2 |
| Seattle Sounders | Vancouver Whitecaps (2) | 0-2 |
|
Day 20 - Scadenza: 20/8, h.01
| Cincinnati | New York City (1) | 2-1 |
| DC United | New England Revolution | 0-3 |
| New York Red Bulls | Nashville SC (3) | 0-1 |
| Orlando City | Chicago Fire | 1-2 |
| Philadelphia Union | Inter Miami (15) | 2-2 |
| Columbus Crew (3) | CF Montreal | 1-2 |
| Toronto FC | Charlotte | 3-3 |
| Sporting Kansas City | St. Louis City (38) | 1-1 |
| Minnesota (5) | Atlanta Utd | 1-2 |
| Colorado Rapids | Los Angeles FC (1) | 1-0 |
| Real Salt Lake | FC Dallas | 3-4 |
| Seattle Sounders (3) | Austin FC | 1-2 |
| Los Angeles Galaxy | San Jose Earthquakes | 1-0 |
| Portland Timbers | San Diego FC | 3-1 |
| Vancouver Whitecaps (1) | Houston Dynamo | 0-1 |
|
Day 21 - Scadenza: 23/8, h.01
| Charlotte | DC United | 3-1 |
| Cincinnati (4) | Seattle Sounders | 1-1 |
| New York Red Bulls (1) | Chicago Fire (4) | 1-1 |
| Orlando City | Real Salt Lake (2) | 2-1 |
| Inter Miami (24) | Toronto FC | 1-2 |
| CF Montreal | Los Angeles Galaxy (1) | 2-2 |
| Nashville SC (18) | Columbus Crew | 3-2 |
| St. Louis City | Houston Dynamo (1) | 2-1 |
| Austin FC (2) | Philadelphia Union (3) | 1-1 |
| Vancouver Whitecaps | FC Dallas | 5-0 |
| Los Angeles FC (2) | Portland Timbers | 1-1 |
| San Diego FC | Colorado Rapids (1) | 3-0 |
| San Jose Earthquakes (3) | Minnesota | 1-5 |
| New England Revolution | New York City | 1-1 |
| Atlanta Utd (6) | Sporting Kansas City | 2-1 |
|
Day 22 - Scadenza: 29/8, h.22
| Seattle Sounders | Chicago Fire (4) | 2-2 |
| Atlanta Utd | Charlotte | 0-2 |
| DC United | Los Angeles FC (3) | 0-0 |
| New York Red Bulls | Philadelphia Union (1) | 1-3 |
| Inter Miami (6) | CF Montreal | 7-1 |
| Toronto FC | New York City (2) | 1-1 |
| Houston Dynamo | San Jose Earthquakes | 0-0 |
| Minnesota | Orlando City | 3-3 |
| Nashville SC (2) | Cincinnati | 4-0 |
| Sporting Kansas City | Vancouver Whitecaps (47) | 0-3 |
| Colorado Rapids | Real Salt Lake | 1-0 |
| Portland Timbers (5) | Austin FC | 1-2 |
| San Diego FC | Los Angeles Galaxy (1) | 3-1 |
| Columbus Crew | New England Revolution (1) | 1-3 |
| St. Louis City | FC Dallas (1) | 3-3 |
|
Day 23 - Scadenza: 5/9, h.01
| New York City | Nashville SC | 5/9 01:30 |
| Charlotte | Houston Dynamo | 6/9 01:30 |
| Cincinnati | DC United | 6/9 01:30 |
| Columbus Crew | Colorado Rapids | 6/9 01:30 |
| Inter Miami | Atlanta Utd | 6/9 01:30 |
| Orlando City | San Diego FC | 6/9 01:30 |
| Philadelphia Union | CF Montreal | 6/9 01:30 |
| Toronto FC | Chicago Fire | 6/9 01:30 |
| Austin FC | San Jose Earthquakes | 6/9 02:30 |
| FC Dallas | Sporting Kansas City | 6/9 02:30 |
| Seattle Sounders | New York Red Bulls | 6/9 02:30 |
| Los Angeles Galaxy | New England Revolution | 6/9 03:30 |
| Real Salt Lake | Los Angeles FC | 6/9 03:30 |
| Portland Timbers | Minnesota | 6/9 04:30 |
| Vancouver Whitecaps | St. Louis City | 6/9 04:30 |
|
Day 24 - Scadenza: 10/9, h.01
| Atlanta Utd | Orlando City | 10/9 01:30 |
| DC United | Columbus Crew | 10/9 01:30 |
| CF Montreal | Charlotte | 10/9 01:30 |
| Toronto FC | Nashville SC | 10/9 01:30 |
| Philadelphia Union | Cincinnati | 10/9 01:30 |
| New York City | New England Revolution | 10/9 02:00 |
| Austin FC | Colorado Rapids | 10/9 02:30 |
| Chicago Fire | Inter Miami | 10/9 02:30 |
| Houston Dynamo | Real Salt Lake | 10/9 02:30 |
| Minnesota | FC Dallas | 10/9 02:30 |
| Los Angeles FC | New York Red Bulls | 10/9 04:30 |
| Portland Timbers | St. Louis City | 10/9 04:30 |
| San Diego FC | San Jose Earthquakes | 10/9 04:30 |
| Seattle Sounders | Sporting Kansas City | 10/9 04:30 |
| Vancouver Whitecaps | Los Angeles Galaxy | 10/9 04:30 |
|
Day 25 - Scadenza: 13/9, h.01
| Cincinnati | Charlotte | 13/9 01:30 |
| Columbus Crew | New York Red Bulls | 13/9 01:30 |
| DC United | Atlanta Utd | 13/9 01:30 |
| Inter Miami | Nashville SC | 13/9 01:30 |
| Orlando City | Toronto FC | 13/9 01:30 |
| FC Dallas | Portland Timbers | 13/9 02:30 |
| Sporting Kansas City | Los Angeles FC | 13/9 02:30 |
| St. Louis City | Minnesota | 13/9 02:30 |
| Real Salt Lake | New York City | 13/9 03:30 |
| Colorado Rapids | CF Montreal | 13/9 03:30 |
| Los Angeles Galaxy | Seattle Sounders | 13/9 04:30 |
| San Jose Earthquakes | Houston Dynamo | 13/9 04:30 |
| Chicago Fire | New England Revolution | 14/9 00:30 |
| Vancouver Whitecaps | Austin FC | 14/9 00:30 |
| San Diego FC | Philadelphia Union | 14/9 03:00 |
|
Day 26 - Scadenza: 19/9, h.01
| New York City | New York Red Bulls | 19/9 01:30 |
| DC United | Charlotte | 20/9 01:30 |
| New England Revolution | Orlando City | 20/9 01:30 |
| San Jose Earthquakes | Los Angeles FC | 20/9 01:30 |
| CF Montreal | Columbus Crew | 20/9 01:30 |
| FC Dallas | Austin FC | 20/9 02:30 |
| Houston Dynamo | Cincinnati | 20/9 02:30 |
| Sporting Kansas City | Philadelphia Union | 20/9 02:30 |
| Minnesota | Los Angeles Galaxy | 20/9 02:30 |
| St. Louis City | Toronto FC | 20/9 02:30 |
| Colorado Rapids | Seattle Sounders | 20/9 03:30 |
| Nashville SC | Chicago Fire | 20/9 03:30 |
| Real Salt Lake | Vancouver Whitecaps | 20/9 03:30 |
| Portland Timbers | Atlanta Utd | 20/9 04:30 |
| Inter Miami | San Diego FC | 21/9 01:00 |
|
Day 27 - Scadenza: 27/9, h.01
| Atlanta Utd | New York City | 27/9 01:30 |
| Charlotte | Chicago Fire | 27/9 01:30 |
| New York Red Bulls | St. Louis City | 27/9 01:30 |
| Philadelphia Union | Orlando City | 27/9 01:30 |
| CF Montreal | Cincinnati | 27/9 01:30 |
| Austin FC | San Diego FC | 27/9 02:30 |
| FC Dallas | Los Angeles FC | 27/9 02:30 |
| Houston Dynamo | Sporting Kansas City | 27/9 02:30 |
| Seattle Sounders | Minnesota | 27/9 02:30 |
| Nashville SC | Toronto FC | 27/9 02:30 |
| Real Salt Lake | New England Revolution | 27/9 03:30 |
| Los Angeles Galaxy | Colorado Rapids | 27/9 04:30 |
| San Jose Earthquakes | Portland Timbers | 27/9 04:30 |
| Vancouver Whitecaps | DC United | 27/9 04:30 |
| Columbus Crew | Inter Miami | 28/9 01:00 |
|
Day 28 - Scadenza: 10/10, h.19
| Toronto FC | CF Montreal | 10/10 19:00 |
| Chicago Fire | New York City | 10/10 20:30 |
| Atlanta Utd | Cincinnati | 11/10 01:30 |
| Charlotte | FC Dallas | 11/10 01:30 |
| Inter Miami | DC United | 11/10 01:30 |
| New England Revolution | Seattle Sounders | 11/10 01:30 |
| New York Red Bulls | San Diego FC | 11/10 01:30 |
| Orlando City | Columbus Crew | 11/10 01:30 |
| Philadelphia Union | Real Salt Lake | 11/10 01:30 |
| Austin FC | Nashville SC | 11/10 02:30 |
| Sporting Kansas City | Portland Timbers | 11/10 02:30 |
| Minnesota | Houston Dynamo | 11/10 02:30 |
| Colorado Rapids | San Jose Earthquakes | 11/10 03:30 |
| Los Angeles FC | Vancouver Whitecaps | 11/10 04:30 |
| St. Louis City | Los Angeles Galaxy | 12/10 01:00 |
|
Day 29 - Scadenza: 15/10, h.01
| Cincinnati | New England Revolution | 15/10 01:30 |
| Columbus Crew | Charlotte | 15/10 01:30 |
| DC United | New York Red Bulls | 15/10 01:30 |
| Inter Miami | New York City | 15/10 01:30 |
| CF Montreal | Atlanta Utd | 15/10 01:30 |
| Toronto FC | Orlando City | 15/10 01:30 |
| Chicago Fire | Philadelphia Union | 15/10 02:30 |
| FC Dallas | Seattle Sounders | 15/10 02:30 |
| Nashville SC | Sporting Kansas City | 15/10 02:30 |
| St. Louis City | Vancouver Whitecaps | 15/10 02:30 |
| Colorado Rapids | Minnesota | 15/10 03:30 |
| Real Salt Lake | San Jose Earthquakes | 15/10 03:30 |
| Los Angeles Galaxy | Portland Timbers | 15/10 04:30 |
| Los Angeles FC | Austin FC | 15/10 04:30 |
| San Diego FC | Houston Dynamo | 15/10 04:30 |
|
Day 30 - Scadenza: 17/10, h.20
| Philadelphia Union | Charlotte | 17/10 20:30 |
| Minnesota | St. Louis City | 17/10 22:30 |
| Atlanta Utd | Inter Miami | 18/10 01:30 |
| New England Revolution | Chicago Fire | 18/10 01:30 |
| Orlando City | DC United | 18/10 01:30 |
| New York Red Bulls | Toronto FC | 18/10 01:30 |
| Houston Dynamo | FC Dallas | 18/10 02:30 |
| Sporting Kansas City | Real Salt Lake | 18/10 02:30 |
| Austin FC | Vancouver Whitecaps | 18/10 02:30 |
| Los Angeles Galaxy | San Diego FC | 18/10 04:30 |
| Portland Timbers | Colorado Rapids | 18/10 04:30 |
| San Jose Earthquakes | Nashville SC | 18/10 04:30 |
| Seattle Sounders | CF Montreal | 18/10 04:30 |
| Cincinnati | Columbus Crew | 19/10 01:00 |
|
Day 31 - Scadenza: 24/10, h.19
| CF Montreal | Nashville SC | 24/10 19:30 |
| Columbus Crew | Toronto FC | 24/10 20:30 |
| New York Red Bulls | Inter Miami | 24/10 22:30 |
| Atlanta Utd | Chicago Fire | 25/10 01:30 |
| DC United | Cincinnati | 25/10 01:30 |
| Orlando City | New York City | 25/10 01:30 |
| Philadelphia Union | New England Revolution | 25/10 01:30 |
| FC Dallas | San Jose Earthquakes | 25/10 02:30 |
| Houston Dynamo | Minnesota | 25/10 02:30 |
| Sporting Kansas City | Austin FC | 25/10 02:30 |
| Real Salt Lake | St. Louis City | 25/10 02:30 |
| Colorado Rapids | Vancouver Whitecaps | 25/10 02:30 |
| Portland Timbers | Charlotte | 25/10 03:30 |
| San Diego FC | Seattle Sounders | 25/10 03:30 |
| Los Angeles FC | Los Angeles Galaxy | 26/10 02:00 |
|
Day 32 - Scadenza: 29/10, h.00
| Inter Miami | Cincinnati | 29/10 00:30 |
| New England Revolution | New York Red Bulls | 29/10 00:30 |
| New York City | Atlanta Utd | 29/10 00:30 |
| Charlotte | CF Montreal | 29/10 00:30 |
| Toronto FC | DC United | 29/10 00:30 |
| Austin FC | Real Salt Lake | 29/10 01:30 |
| Chicago Fire | Orlando City | 29/10 01:30 |
| FC Dallas | Columbus Crew | 29/10 01:30 |
| Minnesota | Sporting Kansas City | 29/10 01:30 |
| Nashville SC | Philadelphia Union | 29/10 01:30 |
| St. Louis City | Portland Timbers | 29/10 01:30 |
| San Jose Earthquakes | Colorado Rapids | 29/10 03:30 |
| Seattle Sounders | Houston Dynamo | 29/10 03:30 |
| Vancouver Whitecaps | San Diego FC | 29/10 03:30 |
|
Day 33 - Scadenza: 31/10, h.18
| Charlotte | Orlando City | 31/10 18:00 |
| Cincinnati | Philadelphia Union | 31/10 19:00 |
| Columbus Crew | DC United | 31/10 19:00 |
| New York City | CF Montreal | 31/10 19:00 |
| Sporting Kansas City | FC Dallas | 31/10 20:00 |
| St. Louis City | San Diego FC | 31/10 20:00 |
| Los Angeles Galaxy | Austin FC | 31/10 22:00 |
| Colorado Rapids | Chicago Fire | 1/11 02:30 |
| San Jose Earthquakes | Real Salt Lake | 1/11 03:30 |
| Nashville SC | New York Red Bulls | 1/11 22:30 |
| Los Angeles FC | Minnesota | 1/11 22:30 |
| Vancouver Whitecaps | Seattle Sounders | 1/11 22:30 |
| Atlanta Utd | Toronto FC | 1/11 22:30 |
| New England Revolution | Inter Miami | 2/11 01:00 |
| Portland Timbers | Houston Dynamo | 2/11 03:15 |
|
Day 34 - Scadenza: 7/11, h.22
| Chicago Fire | Columbus Crew | 7/11 22:00 |
| Cincinnati | Nashville SC | 7/11 22:00 |
| DC United | New York City | 7/11 22:00 |
| Inter Miami | Charlotte | 7/11 22:00 |
| New York Red Bulls | Atlanta Utd | 7/11 22:00 |
| Orlando City | New England Revolution | 7/11 22:00 |
| CF Montreal | Vancouver Whitecaps | 7/11 22:00 |
| Philadelphia Union | Toronto FC | 7/11 22:00 |
| Austin FC | Portland Timbers | 8/11 01:00 |
| FC Dallas | Colorado Rapids | 8/11 01:00 |
| Houston Dynamo | St. Louis City | 8/11 01:00 |
| Minnesota | San Jose Earthquakes | 8/11 01:00 |
| Real Salt Lake | Los Angeles Galaxy | 8/11 01:00 |
| San Diego FC | Sporting Kansas City | 8/11 01:00 |
| Seattle Sounders | Los Angeles FC | 8/11 01:00 |
|
Round One - Game 1 - Scadenza: 11/11, h.02| Partite non impostate |
|
Round One - Game 2 - Scadenza: 14/11, h.20| Partite non impostate |
|
Round One - Game 3 - Scadenza: 17/11, h.01| Partite non impostate |
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Conference Semifinals - Scadenza: 20/11, h.03| Partite non impostate |
|
Conference Finals - Scadenza: 23/11, h.00| Partite non impostate |
|
MLS CUP - Scadenza: 26/11, h.20| Partite non impostate |
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